Background

Over the last 10-15 years, it has become increasingly clear that a significant proportion of infertility is caused by genetic abnormalities. Bridge Genoma is committed to providing accurate genetic tests for the improvement of both diagnosis and treatment.

Some useful references on genetics and infertility:

Reproductive medicine: molecular, cellular and genetic fundamentals (2003) (eds Fauser, B.C.J.M., Bouchard, P., Hsueh, A.J.W., Rutherford, A.J., Simpson, J.L. and Strauss, III, J.F.) Parthenon Publishing Group, Carnforth, Lancs.

Giudice, L.C. and Kao, L.C. (2004) Endometriosis Lancet 364, 1789-99.

Schlessinger, D.; Herrera, L.; Crisponi, L.; Mumm, S.; Percesepe, A.; Pellegrini, M.; Pilia, G., and Forabosco, A. (2002) Genes and translocations involved in POF. Am J Med Genet. 111, 328-33.

Kobayashi, A. and Behringer, R.R. (2003) Developmental genetics of the female reproductive tract in mammals. Nature Reviews Genetics 4, 969-980.

Ostermeier, G.C., Dix, D.J., Miller, D., Purvesh, K. and Krawetz, S.A. (2002) Spermatozoal RNA profiles of normal men Lancet 360, 772.

Moldenhauer JS, Ostermeier GC, Johnson A, Diamond MP, Krawetz SA. (2003) Diagnosing male factor infertility using microarrays. J Androl. 24, 783-9.

Vogt, P.H. (2004) Azoospermia factor (AZF) in Yq11: towards a molecular understanding of its function for human male fertility and spermatogenesis. Reprod Biomed Online 10, 81-93.